Efficacy and safety of second-line ponatinib after failure of a single previous tyrosine kinase inhibitor for chronic myeloid leukemia patients in chronic phase

Ponatinib (Iclusig, ARIAD Pharmaceuticals) is a 3rd-generation structure-guided, rationally designed tyrosine kinase inhibitor (TKI) aimed at overcoming the resistance of the T315 mutation. Ponatinib is currently indicated for adult Philadelphia positive (Ph+) chronic myeloid leukemia (CML) patients in all phases of disease resistant and/or intolerant to dasatinib or nilotinib, for whom imatinib is not clinically indicated or for patients with identified T315I mutation or adult Ph+ acute lymphoid leukemia resistant or intolerant to dasatinib, for whom imatinib is not appropriate or with identified T315I.1 The phase II PACE trial showed 50%–60% of heavily pretreated patients were rescued, allowing a major cytogenetic response (McyR) to be achieved.2 The majority of patients enrolled in the PACE trial had received at least two prior TKIs and only limited information was available in reports of a failure or severe intolerance to 2nd-generation TKI started as front-line treatment. Overall, in the trial, only 6 patients were reported to have received ponatinib as second-line treatment. We read with great interest the letter by Sanford et al., which described 5 patients who received ponatinib as second-line treatment (3 after imatinib and 2 after dasatinib failure) included in a phase II trial that prematurely closed after FDA recommendations based on safety concerns.3 We here describe a series of 10 patients who switched to ponatinib as second-line treatment, the majority after failure of front-line 2nd-generation TKI. Median age was 55.7 years (range 35.7–71.8 years) According to the Sokal Risk Score, one patient was classified as low risk, 7 as intermediate risk, and 2 as high risk (Table 1). According to the EUTOS score, only 3 patients were classified as high risk. Only one patient had an additional cytogenetic aberration in the Ph+ clone (ACA) at baseline. Eight patients were treated with front-line 2nd-generation TKI (4 with nilotinib 300 mg BID and 4 with dasatinib 100 mg QD), whereas 2 patients were treated with imatinib 400 mg QD, and both had T315I mutation. Four patients treated with 2nd-generation TKIs switched to ponatinib for primary resistance (3 to dasatinib and 1 to nilotinib), whereas another 4 patients switched for secondary resistance [loss of complete cytogenetic response (CCyR)]. Median time to switch to ponatinib was 16 months. Initial dose was 45 mg/day in 5 patients and 30 mg/day in 5 patients. Two patients did not reach an optimal response after switching; both experienced a severe thrombocytopenia and one patient with primary resistance subsequently progressed to blast phase and died. Four patients (40%) achieved an MR3 as best response, whereas 4 patients (40%) achieved an MR4; 2 patients reduced the dose from 45 mg to 30 mg due to a skin rash. As regards safety, 2 patients experienced hypertension (successfully treated with antihypertensive medication), 4 patients had skin rash, one patient had increased lipase. No arterial or venous thrombotic events were observed in any patients. Only one patient died after progression to blast phase. Two patients who switched from imatinib to ponatinib for T315I mutation achieved an MR4. All patients had long-lasting responses. No other mutations were observed at baseline or during treatment.