Dihydrochalcone designed from methylophiopogonanone B strongly inhibits hypoxia-inducible factor (HIF)-1α activity

Inhibition of hypoxia-inducible factor (HIF)-1α activity of methylophiopogonanone B (1) and its derivatives were investigated. As the modification of the structure of 1, dihydrochalcone (11) was leaded and showed one order higher activity (IC 50 : 0.2 μg/mL) than methylophiopogonanone B (1) (IC 50 : 2.2 μg/mL).