Cost–consequence analysis of a hemostatic matrix alone or in combination for spine surgery patients

AbstractBackground: A five-year retrospective database analysis comparing the use of Floseal1 flowable topical hemostat alone (F) and in combination with gelatin/thrombin (F + G/T) to achieve hemostasis and control surgical bleeding showed higher resource utilization for F + G/T cases relative to F matched pairs during spinal surgery. Lower resource use in the F group was characterized by shorter hospital length of stay and surgical time as well as fewer blood transfusions and less hemostat agent used per surgery.Objective: To evaluate the cost–consequence of using F compared to F + G/T in minor, major and severe spinal surgery from the US hospital perspective.Methods: A cost–consequence model was developed using the US hospital perspective. Model inputs include clinical inputs from the literature, cost inputs (hemostatic matrices, blood product transfusion, hospital stay and operating room time) from the literature, and an analysis of annual spine surgery volume (minor, major and severe) using the 2012 N...