Codon optimized severe fever associated thrombocytopenia syndrome virus nucleoprotein gene and nucleic acid vaccine thereof

The invention belongs to the technical filed of biological medicines, and relates to a codon optimized severe fever associated thrombocytopenia syndrome virus nucleoprotein gene and a nucleic acid vaccine thereof. The sequence of the codon optimized gene considers the codon usage bias of mammal cells, and is represented by SEQ ID NO.2. The severe fever associated thrombocytopenia syndrome virus nucleoprotein nucleic acid vaccine is composed of the codon optimized severe fever associated thrombocytopenia syndrome virus nucleoprotein gene sequence and an eukaryotic expression vector pJW4303, and the 5' end of the sequence is connected with a tPA signal peptide sequence. The nucleic acid vaccine effectively stimulates the immune system after immunizing mammals, and generates good humoral immune response.