Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Intraoperative Chemotherapy (Hipec) for Recurrent Squamous Cell Carcinoma of the Pancreas

Background/Aims: Squamous cell carcinoma of the pancreas is a rare entity and its histogenesis is not adequately understood. Surgical resection is the only potentially curative option. Recurrent local-regionally pancreatic carcinomas are usually inoperable and are treated with palliative intent. The purpose of the study is to present the treatment strategy of a recurrent squamous cell pancreatic carcinoma with peritoneal carcinomatosis. Case Report: A 49-year-old man with local-regional recurrent squamous cell pancreatic carcinoma underwent complete (CC-0) cytoreductive surgery (CRS) and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC). In a 6-month time he underwent secondary CRS+HIPEC for regional recurrence. Despite treatment with adjuvant systemic chemotherapy the patient died 12 months after the initial CRS with osseous metastases. Conclusions: A reliable prognosis for recurrent squamous cell pancreatic carcinoma is impossible despite complete cytoreduction in combination with HIPEC and systemic chemotherapy.