Insulin-Dependent Diabetes Mellitus Review

disease with the highest incidence (1%‐1.5% in Finland) being in northern Europe, with decreasing incidence the NOD mouse, and the Bio-breeding rat, as well as in more southerly and tropical locations. Although this the use of NOD mice transgenic for several MHC class suggests the effect of infectious agents, in the nonobese II molecules, has revealed a complex interplay between diabetic (NOD) mouse, germ-free NOD mice have the alleles of the two major isotypes of MHC class II molehighest incidence (nearly 100%) that has been seen in cules (HLA [human leukocyte antigen] DR and DQ in any NOD colony.