The diagnostic value of endonasal provocation with chemical antigens in occupational respiratory allergoses

: Allergologic study covered 500 workers who underwent exposure to hexavalent chromium and 150 workers exposed to formaldehyde. The study proved high specificity and diagnostic value of endonasal provocation with hapten. Endonasal provocation with chemical antigen helps to disclose an etiologic role of the hapten in upper and lower respiratory tract allergy. Endonasal provocation with chemical allergen reveals latent sensibilization of respiratory tract mucosa in apparently healthy workers with no allergic signs. The data obtained could be valuable for diagnosis of occupational allergies, for examination of capacity to work, for occupational examinations, for rational medical and occupational rehabilitation.