Ordering of the human regulator of complement activation gene cluster on 1q32 by two-colour FISH.

The regulator of complement activation (RCA) gene cluster and PTPRC and REN genes have been mapped to the 1q31→q32 band interval. We have used two-colour in situ hybridization to determine the chromosomal position of these genes. We report here that HF1/F13B are proximal to the C4BP/MCP genes. We also propose that PTPRC and REN genes map to a region of the RCA gene cluster between the HF1/F13B and C4BP/MCP regions. In summary, we propose the following gene order: centromere-HF1/F13B-PTPRC-REN-C4BP/MCP-telomere.