Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia carrying variants of -28A > G and IVS-II-654C > T in HBB.

Abstract β-thalassemia is mostly caused by homozygous or compound heterozygous variants in HBB. We generated a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with β-thalassemia major, carrying compound heterozygous -28A>G and IVS-II-654C>T variants in HBB gene. This line will be a valuable resource for disease modeling and testing gene therapies for β-thalassemia.