Tumor Production in Rats Injected Intravenously with Oil Emulsions Containing 9,10-Dimethyl-1,2-Benzanthracene

The intravenous administration of fat emulsions which contained 9,10-dimethyl-1,2-benzanthracene caused a high incidence of skin tumors in female rats of the Sprague-Dawley strain. Fifty-five per cent of the surviving animals developed keratinizing squamous-cell tumors of the sebaceous gland type and/or adenocarcinomas which were usually located over the course of the “mammary line” on the ventral surface of the trunk. Only two animals developed neoplasms which were not of skin or dermal adnexae derivative.