Behçet's disease: a diagnostic challenge in rheumatology. Description of a case series and a review of the literature

Abstract Behcet's disease is a clinical autoinflammatory disorder of unknown etiology, usually with systemic manifestations, and a pattern of exacerbation-remission, often associated with delayed diagnosis. The diagnosis of this disease is complex. This article discusses four cases of patients with Behcet's disease, who during the clinical approach were considered to have other autoimmune diseases. A comprehensive review of the medical history, the development of oral and genital ulcers, in addition to the study of major histocompatibility complex typing (HLA), enabled the diagnosis of Behcet's disease.