Immunobiological activity of various blood serum fractions from cattle and swine. The dynamics of Ig in specific serum against colibacillosis in pigs

: The level of the IgM and IgG agglutinating antibody specific hyperimmune serum against coli-bacteriosis and its fractions were studied. The serum was obtained at various stages of the preparation, hyperimmunization and exploitation of serum producing swine by using the 2-mercapto-ethanol test. It was established that serum of the total globulin, alpha-beta-globulin and gamma-globulin fractions contains IgM and IgG agglutinating antibodies against E. coli. These immunoglobulin classes are synthetized at all stages of serum producing swine preparation, hyperimmunization and exploitation. The quantitative IgM:IgG ratios at the individual stages vary. At the initial stages and until the 10th cycle of exsanguination (phlebotomy) IgM antibodies predominate. After that, at the following stages IgG antibodies begin gradually to predominate. Up to the 20th cycle of exsanguination both globulins are synthetized, but the 2-mercapto-ethanol non-sensitive IgG antibodies are in greater quantity.