input synthetic internal ribosome sites and methods of identifying them

"Sites of synthetic RIBOSOME INTERNAL INPUT AND METHODS TO IDENTIFY THE SAME." Isolated regulatory elements translational and synthetic, including oligonucleotides having translational enhancement activity, activity entry site internal ribosome (IRES) or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, such compositions include translational regulatory elements are provided, as are methods of use of translational regulatory elements.