Cerebrospinal fluid p24 antigen levels and intrathecal immunoglobulin G synthesis are associated with cognitive disease severity in HIV-1

ObjectiveTo test the hypothesis that selected cerebrospinal fluid (CSF) markers [intrathecal immunoglobulin G (IgC) synthesis rate, oligoclonal IgC bands, and p24 antigen levels] are associated with the presence and severity of clinical HIV-1 neurologic disease.Design and methodsCSF and blood parame