阿托伐他汀联合替格瑞洛治疗急性冠脉综合症介入术后患者两种药物临床疗效的相互影响 The Mutual Effect of Clinical Efficacy of Atorvastatin Combined with Ticagrelor for Patients with Acute Coronary Syndrome after Interventional Treatment

目的：探究急性冠脉综合症患者介入术后使用阿托伐他汀与替格瑞洛联用两种药物临床效果及其副作用的相互影响。方法：收集我院2014年心内科入院患者120例，经临床症状和冠脉造影诊断为急性冠脉综合症，将入选患者随机分为阿托伐他汀氯吡格雷组、阿托伐他汀替格瑞洛组，测定各组患者血清尿酸、转氨酶、肌酸激酶、血小板聚集率、血脂水平等，比较在临床疗效上是否存在相互影响。结果：与氯吡格雷组相比，替格瑞洛组在抗血小板聚集率有统计学意义(P 0.05). Conclusions: Studies have shown competitive inhibition of CYP3A4 between atorvastatin and ticagrelor, resulting in certain influence on the pharmacokinetics, however, their clinical efficacy showed no significant change in the short term when used in combination.