Original and General Strategy of Dimerization of Bioactive Molecules
2001
Dimerization of an active compound often results in enhanced binding and improved pharmacological properties. This potency is attributed to a higher concentration of pharmacophores in the proximity of recognition sites. This bivalent ligand approach is generally presumed to use a symmetrical bifunctional linker X to anchor two substrates P, giving rise to the general structure P-X-P [1].
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