FARKLI ENDODONTİK YIKAMA SOLÜSYONLARININ TOKSİK VE NEKROTİK DOKU ÇÖZÜCÜ ETKİLERİNİN KARŞILAŞTIRMALI OLARAK İNCELENMESİ-COMPARATIVE INVESTIGATION OF THE TOXIC AND NECROTIC TISSUE-DISSOLVING EFFECTS OF DIFFERENT ENDODONTIC IRRIGANTS

Ozet Bu calismanin amaci Cetrexidin ve klorheksidin gluko-nat'i, toksik ve nekrotik doku cozucu etkileri bakimindan iki farkli konsantrasyondaki (% 5.25 ve %0.5) sodyum hipoklorit (NaOCI) ile karsilasarmau olarak incelemektir. Calismada %5.25'lik NaOCI pozitif kontrol, serum fizyolojik ise negatif kontrol olarak kullanilmistir. Calismanin birinci bolumunde herbir yikama solusyonunun 0.1 ml'si tavsanin sirt bolgesinde daha once belirlenen bolgelere cilt alti bag dokusuna enjekte edildi. Enjeksiyon bolgeleri 2 saat, 48 saat ve 2 hafta sonra histopatolojik olarak incelendi ve olusan doku reaksiyonlari degerlendirildi. Ikinci bolumde yikama solusyonlarinin nekrotik sigir kas dokusu uzerindeki cozucu etkileri incelendi. Calisma sonunda; iki saatlik periyotta tum solusyonlarin hafif yangi olusturdugu gozlendi. %5.25'lik NaOCI 48 saat ve 2 haftada siddetli yangisal doku reaksiyonlarina sebeb olurken; diger test solusyonlarinin 48 saatte orta siddette yangi olusturdugu; 2 hafta sonra olusan yanginin en az duzeye geriledigi saptandi, iki haftalik periyotta negatif kontrol disinda tum deney gruplarinda fibrozis gozlendi, %5.25'lik NaOCI'in, %0.5iik NaOCI'e oranla daha etkili bir nekrotik doku cozucu oldugu, Cetrexidin ve klorheksidin glukonaon nekrotik doku cozucu etkisinin %0.5'lik NaOCI'den bile dusuk oldugu saptandi. Anahtar sozcukler: klorheksidin, nekrotik doku cozucu etki, setrimit, sodyum hipoklorit, toksik etki Abstract The purpose of this study was to compare the necrotic tissue-dissolving and toxic effects of Cetrexidin and chlorhexidine gluconate with those of two different dilutions (5.25% and 0.5%) of sodium hypochlorite (NaOCI). 5.25% NaOCI and sterile saline were used as positive and negative controls, respectively. In the first part of the study, 0.1 ml of each test solution was injected subcutaneously into predetermined areas on the rabbit dorsum. Test areas were histologically examined 2 hours, 48 hours and 2 weeks after the injections. In the second part, dissolving effect of the irrigants was studied on the necrotic bovine muscular tissue. The results of this study showed that all test solutions exhibited mild inflamation at 2 hours. While 5.25% NaOCI caused the severe inflamatory tissue reactions at 48 hours and 2 weeks, other solutions exhibited moderate inflamation at 48 hours; after 2 weeks, the severity of inflamation was decreased to the mild rate. The fibrosis was observed in aU experimental groups except for negative control. 5.25% NaOCI was significantly more effective than 0.5 % NaOCI as a necrotic tissue solvent Necrotic tissue-dissolving effect of Cetrexidin and chlorhexidine gluconate was less effective than 0.5% NaOCI. Key words: cetrimide, chlorhexidine gluconate, necrotic tissue-dissolving effect, toxic effect, sodium hypochlorite