Patient-Specific Biomechanics in Marfan Ascending Thoracic Aortic Aneurysms

Abstract Background Guidelines for Sinus of Valsalva-thoracic aortic aneurysms (SOV-TAA) in Marfan syndrome recommend size-based criteria for elective surgical repair. Biomechanics may provide a better prediction of dissection risk than diameter. Our aim was to determine magnitudes of wall stress in the aortic root of Marfan patients using finite element analyses. Methods Forty-six Marfan patients underwent patient-specific 3D SOV-TAA geometry reconstruction using imaging data. Finite element analyses were performed to determine wall stress distributions at SOV, sinotubular junction (STJ), and ascending aorta (AscAo) at systole. Results Peak circumferential stresses were 432.8±111kPa, 408.1±88.3kPa, and 321.9±83.8kPa at the SOV, STJ, and AscAo, respectively with significant differences between SOV and AscAo (p Conclusions Peak wall stresses in Marfan SOV-TAA were greatest in SOV than STJ than AscAo. Diameter was poorly correlated to peak stresses such that current guidelines with 5cm cutoff had significant overlap in peak stresses in patients with