The New Massive Data: miRnomics and Its Application to Therapeutics

Genomic medicine is highly dependent on understanding the biological processes regulating gene expression. In this reference, the discovery of phenomena of RNA interference in 1998 served as turning point for the field of genomic medicine. It was observed that the double stranded RNA (dsRNA) is capable of silencing specific genes in Caenorhabditis elegans [12]. Later, studies on RNA interference have revealed that RNA interference operates in many species and serves in silencing genes. In C. elegans, the inhibitory potential of RNA was induced by introducing endogeneous long dsRNA’s while in mammalian cells, the introduction of small 21 nt RNA’s could induce RNAi. [10].