5α-reductase type 3 expression in human benign and malignant tissues: A comparative analysis during prostate cancer progression†

BACKGROUND A third isozyme of human 5α-steroid reductase, 5α-reductase-3, was identified in prostate tissue at the mRNA level. However, the levels of 5α-reductase-3 protein expression and its cellular localization in human tissues remain unknown.