Molecular analysis for medicine: a new technological platform based on nanopatterning and label-free optical detection

In this contribution, we show that by biopatterning probe molecules at the nanoscale using soft-lithography, we can produce protein biochips at a cost sufficiently small for their use as a systematic method of molecular analysis for medical diagnosis purposes. The combination of multiplexed nanoscale Micro-Contact printing and label-free optical detection using the principle of light diffraction, is implemented for generating engineered glass slides of analysis and a dedicated diffractive scanner for reading the multiplexed results of an assay.