Clinical, Demographic, and Imaging Correlates of Anemia in Heart Failure with Preserved Ejection Fraction (From the RELAX Trial)

Abstract Anemia is a commonly occurring comorbidity among patients with heart failure with preserved ejection fraction (HFpEF) but limited data exists on the cardiovascular phenotype of anemia in HFpEF. We sought to characterize the clinical features, exercise capacity and outcomes in patients with HFpEF to elucidate the phenotype and pathophysiology of anemia in HFpEF. Post-hoc analyses of participants enrolled in the RELAX (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure) trial was performed. Anemia was defined as hemoglobin