Дополнительный иммунологический критерий ранней диагностики первичной открытоугольной глаукомы

Background. System (blood) and local (lacrimal fluid) products of interleikin-17 (IL-17) were studied in patients with primary openangle glaucoma (POAG) and in patients at risk of developing glaucoma. Methods. 80 patients with POAG and 35 patients at risk group (myopia, hypertensive disease I-II stage, diabetes of II-type) were examined, control group 30 apparently healthy volunteers. Results. System and local hyperproduction of IL-17 at POAG was detected, which is an evidence of cytokine participation in chronic immune inflammation. Conclusions. In patients with hypertension the production level of IL-17 does not relate to the risk development of glaucoma. At diabetes of II type IL-17, in lacrimal fluid more than 1,44 pg/ml, demonstrated a high risk development of POAG. In patients with myopic refraction with and without glaucoma there were registered the most significant increase of IL-17 concentration. Local level of IL-17 more than 3,22 pg/ml in patients with myopia may be considered as additional early marker of POAG diagnosis.