The engine driving the ship: metabolic steering of cell proliferation and death
2010
Metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, including D-type cyclins, CDKs, APC, p53, caspase 2 and BCL-2 proteins. The importance of this crosstalk is emphasized by the role of metabolic aberrations in the aetiology of disease.
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