Role of endogenous eicosanoids in the antiulcer effect of kaempferol

Kaempferol has been found to possess, at doses of 50-200 mg/kg ip, antiulcer effects against ethanol and cold restraint stress-induced gastric damage in rats. Study on the release of eicosanoids by human gastric and colonic mucosal incubates showed that 1 μg/ml of kaempferol enhanced PGE release by human gastric mucosa, while 100 μg/ml tended to inhibit prostanoid and leukotriene C 4 release both by human gastric and colonic mucosal incubates. The antiulcer effect of kaempferol could be explained by its effect on leukotriene C 4 and PGE which, as known, play an important role in the etiology of gastrointestinal mucosal damage.