The Importance of Acetonitrile in the Pharmaceutical Industry and Opportunities for its Recovery from Waste

Acetonitrile is regarded as a key solvent in the pharmaceutical industry. However, the volatility in acetonitrile supply in recent years, coupled with its relatively poor environmental profile, has presented significant challenges to its use in manufacturing processes and laboratories. This study investigates the importance of acetonitrile in the pharmaceutical industry and critically examines several options for reducing the exposure of the industry to future supply problems whilst also improving its life cycle management. The physicochemical properties of acetonitrile were compared with other typical process solvents and the Conductor-like Screening Model (COSMO) surfaces and sigma profiles were used to help explain the favorable solvation behaviour of acetonitrile. Several options for the replacement or recovery and recycle of acetonitrile were critically examined in the contexts of environmental, technical, and economic feasibility. Azeotropic distillation was found to be the most likely approach to r...