2.213 Improved antiparkinsonian effects during the night with levodopa/dopa decarboxylase inhibitor and entacapone compared with levodopa/dopa decarboxylase inhibitor in Parkinson's disease patients experiencing symptom re-emergence due to wearing-off

examined using multivariate regression to control for pre-index MPR with LC and other patient characteristics. Results: Satisfactory adherence (n = 617) compared with unsatisfactory adherence (MPR< 80%, n = 598) was associated with a 39% reduction in PD-related hospitalization (95% confidence interval [CI]: 20−54%; p< 0.001), a 47% reduction in all-cause inpatient costs (95%CI: 18−65%; p = 0.004) and an 18% reduction in all-cause total costs (95%CI: 11−24%; p< 0.001). On an adjusted basis, patients with satisfactory adherence had costs of $3508 less than those with unsatisfactory adherence. Results were qualitatively similar in those receiving LCE or LC and E. Conclusion: Better adherence to therapy is associated with reduced PDrelated and all-cause medical care utilization and lower treatment costs. Strategies to improve treatment adherence, may result in substantial cost savings.