Withdrawal of high-carbohydrate high-fat diet alters status of trace elements to ameliorate metabolic syndrome in rat

Abstract Introduction Inadequate nutrient supply and insulin resistance help in the pathogenesis of metabolic syndrome (MetS) and increase the risk of developing cardiovascular disease. MetS can be induced by the prolonged feeding of high-carbohydrate high-fat (HCHF)-diet. The present study was designed taking Wistar albino rats as model for human to investigate the effect of sub-chronic withdrawal of HCHF-diet during MetS on distribution of copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), zinc (Zn), and chromium (Cr) in different biological media. Methods: The experimental animals were fed HCHF-diet up-to 16 weeks for inducing MetS. After inducing MetS, few animals were shifted to basal diet for next 4 weeks. Distribution of TE in serum, liver, and feces at the different time interval and also their relationship with dietary TE were analyzed. Results On withdrawal of HCHF-diet, concentrations of Zn, Mg, Mn (serum, p Conclusion Consumption of HCHF-diet for a long time leads to alteration of TE profile in serum, liver, and feces during MetS, which is reversed upon dietary intervention and this, can be correlated with their concentrations in HCHF and basal diet and hence can contribute to the proper dietary control of this global issue.