1133 P27KIP1 DOWN-REGULATES EGFR EXPRESSION VIA INHIBITION OF JNK/C-JUN TRANSACTIVATION: A NOVEL FUNCTION OF P27KIP1 IN TUMOR SUPPRESSION DEFICIENT IN METASTATIC BLADDER CANCER CELLS

MLH1 expression might be involved in tumor pathogenesis and progression of some UCBs. Although we did not find loss of MLH1 to be associated with pathologic stage or grade, its association with decreased cancer-specific survival suggests that MLH1 may be a potentially useful prognostic biomarker for UCB. MSH6 and MGMT expression, in our cohort, were not significant predictors of UCB behavior. Evaluation of mismatch repair proteins MSH2 and PMS2 is ongoing.