Emodin derivates and its application in the medicine of AntiHIV1 RT activity 1 is prepared

The invention discloses the acetic acid rheum emodin of emodin derivates 3 and 1, application of the 8 two hexanoyl rheum emodins in the medicine of AntiHIV1 RT activity 1 is prepared, belong to antiviral drugs field.The present invention is prepared for 3 acetic acid rheum emodins and 1,8 two hexanoyl rheum emodins by chemical synthesis, and finds that it has the function that to suppress the virus replications of HIV 1 in vitro, and viral inclusion body is significantly reduced in the human macrophage of infection, and human macrophage is had no toxic side effect.Increase in vitro with 3 acetic acid rheum emodins or 1,8 two hexanoyl rheum emodin concentration, it strengthens the inhibitory action that HIV 1 is replicated, and Gag gene and p24 protein expressions gradually reduce；Meanwhile as drug treating time is longer, it is more notable to suppress the effect that HIV 1 infects.3 acetic acid rheum emodins and 1,8 2 hexanoyl rheum emodins can be used for the medicine for preparing AntiHIV1 RT activity 1.