Method for detecting content of relevant substances of Ticagrelor

2016 
The invention aims at providing a method for detecting the content of relevant substances of Ticagrelor. The method is high in precision, easy to operate and high in applicability. The method includes the following steps that firstly, a system applicability solution is prepared, wherein compound hydroxyl, amino compounds, sulfoxide 1, sulfoxide 2, sulfone, photodegradation products, five-membered ring compound hydroxyl, transposition products, ethyl esterification matter, process intermediates 3 and Ticagrelor are prepared into the system applicability solution; secondly, a test solution is prepared, wherein Ticagrelor raw materials are taken and prepared into the test solution; thirdly, a contrast solution is prepared, wherein the test solution is taken and prepared into the contrast solution; fourthly, the system applicability solution, the contrast solution and the test solution are injected into a liquid chromatographic instrument, and chromatograph charts are obtained; fifthly, according to the chromatograph charts of the system applicability solution, the contrast solution and the test solution, the content of the relevant substances in the test solution is calculated.
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