Serial measurement of hepatic lipids during chemotherapy in colorectal cancer patients: A 1H magnetic resonance spectroscopy study

Background and Rationale Hepatic steatosis is a hallmark of chemotherapy-induced liver injury. We made serial 1H magnetic resonance spectroscopy (MRS) measurements of hepatic lipids in patients over the time course of a 24-week chemotherapy regimen to determine whether 1H MRS can be used to monitor the progression of chemotherapy-induced steatosis.