Pharmaco-Informatics: Accelerated NPEM Population Pharmacokinetic Modeling, “Maximum Entropy” (ME) Parameter Distributions, and New “Multiple Model” (MM) Stochastic Dosage Regimens now by Oral, IM, and both Intermittent and Continous IV

Abstract New techniques have greatly increased the speed of NPEM population analysis 20 to 30-fold. Development of ME parameter distributions now permits use of literature population parameter values to create discrete probability density functions (PDF's) for MM dosage design. The MM regimens are no longer limited to the continous IV route, but have now been extended to include all common routes. NPEM population analysis is much more practical and feasible. ME parameter distributions now permit informed yet sceptical use of literature data of drug behavior. The full implementation of MM stochastic control of dosage regimens by all routes now permits essentially full use of information, either in an NPEM or ME population pharmacokinetic model, to achieve and maintain selected therapeutic goals with maximal precision, including after Bayesian updating of parameter PDF's as serum drug levels are obtained.