Influence of Shenkang Injection Combined with Irbesartan on Trace Albumin Excretion and Blood Rheology of Early Diabetic Nephropathy Patients

Objective:To observe the influence of Shenkang injection combined with irbesartan on urinary albumin excretion rate(UAER)within 24 hours,serum lipid,and blood rheology of patients with early diabetic nephropathy.Methods:One hundred and fifty normotensive early diabetic nephropathy patients were randomly divided into control group(group C),Shenkang injection group(group S)and Shenkang and Irbesartan combination group(group SI).All of them were given diabetic education,and carried out dietary regimen,and suitable movement.In the same time,oral anti-hyperglycemic agents were given to them till their fasting blood glucose(FBG)was less than 7.0 mmol/L and postprandial blood glucose(PBG)less than 10.0 mmol/L.Besides,patients in group C were treated with oral anti-hyperglycemic agents or/and insulin,those in group S were treated with Shenkang injection 100 ml mixed with 5% glucose 250~300 ml plus 2~3 U of insulin intravenously guttaed once a day,and those in group SI were treated like group S but plus Irbesartan 0.15 g once a day orally.A treatment course was 3 weeks and the experiment lasted 3 courses.The levels of UAER,serum lipid and blood rheology were detected and compared before and after the treatment.Results:UAER,and serum lipid of patients in groups S and SI after treatment were significantly lower than those before and their blood rheology indexes were improved(P0.01).All the improvements were better than those in control group(P0.05),of which the amelioration of the disease was not obvious.The improvements in group SI were better than those in group S(P0.05).Conclusions:Shenkang injection can reduce UAER,decrease serum lipid,and improve renal blood rheology.It effectively prevents diabetic nephropathy in earlier period and may have joint-action with Irbesartan.