EFFECTS OF FETAL AND NEONATAL HYPERINSULINISM ON GLUCOSE HOMEOSTASIS

Infants with persistent hyperinsulinism (HI) provide an excellent opportunity for studying the effect of insulin induced hypoglycemia (H) on glucoregulatory hormones and substrates. A total of 4 patients, 3 boys and 1 girl, ages 12-39 days, were studied. Three were found to have nesidioblastosis, one had a microadenoma of the pancreas.