Generic MS-based method for the bioanalysis of therapeutic monoclonal antibodies in nonclinical studies

Noritaka Hashii,Yoshiko Tousaka,Koji Arai,Ryoya Goda,Noriko Inoue,Kazuyuki Murata,Takeshi Okuzono,Satomi Sasahara,Takuma Shigeyama,Hidehisa Tachiki,Shinichi Yamane,Yoshiro Saito,Akiko Ishii-Watabe

Generic MS-based method for the bioanalysis of therapeutic monoclonal antibodies in nonclinical studies

2020

Noritaka Hashii
Yoshiko Tousaka
Koji Arai
Ryoya Goda
Noriko Inoue
Kazuyuki Murata
Takeshi Okuzono
Satomi Sasahara
Takuma Shigeyama
Hidehisa Tachiki
Shinichi Yamane
Yoshiro Saito
Akiko Ishii-Watabe

Aim: A generic bioanalytical method was developed to quantify therapeutic IgG1 monoclonal antibodies (mAbs) in mouse sera by combining an easy sample preparation method with LC/MS using selected re...

Keywords:

Bioanalysis
Selected reaction monitoring
Monoclonal antibody
Chemistry
Liquid chromatography–mass spectrometry
Chromatography
Sample preparation

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