Polikistik Over Sendromlu Adölesanlarda Serum Ürokortin 2, Ürokortin 3 ve Antimüllerian Hormon Düzeyleri

Amac: Polikistik over sendromu (PKOS) kronik anovulasyon ve hiperandrojenizm ile karakterize, ureme cagindaki kadinlarin %5-10’unu etkileyen yaygin bir endokrin bozukluktur. PKOS’lu adolesanlarda serum urokortin 2 ve urokortin 3 ve Antimullerian Hormon (AMH) duzeylerinin arastirilmasi ve saglikli kontroller ile karsilastirilmasi amaclanmistir. Gerec ve Yontem: Calismaya Rotterdam kriterlerine gore PKOS tanisi alan (ortalama yas: 16.1±0.98 yil) 37 adolesan ve 39 saglikli (ortalama yas: 16.1±1.08) kontrol olmak uzere 76 adolesan alindi. Tum hastalarin antropometrik olcumleri ve pubertal gelisim evreleri kaydedildi. Modifiye Ferriman- Gallwey skorlama sistemine gore hirsutizm skorlamasi yapildi. Homa-IR >4 degeri insulin direnci olarak kabul edildi. Biyoelektriksel impedans analizi ile olgularin vucut yag-kas orani degerlendirildi. Aclik serum glukoz, insulin, lipit, Follikul Stimule Edici Hormon, Luteinlestiren Hormon, Seks Hormonu Baglayici Globulin, Serbest Testosteron, Total Testosteron duzeyleri olculdu. USG ile PKOS tanisi alan olgularin over morfolojileri degerlendirildi. Bulgular: Her iki grup arasinda yas ortalamasi acisindan fark saptanmadi (p>.05). PKOS’lu grupta VKI SDS, boy SDS ve bel cevresi SDS kontrol grubundan daha yuksek bulundu (p .05). Hirsutizm siddeti ile AMH, urokortin 2 ve 3 duzeyleri arasinda iliski saptanmadi (p>.05). AMH, urokortin 2 ve urokortin 3 arasinda anlamli pozitif korelasyon tespit edilirken, LH, FSH, serbest testosteron, total testosteron ve SHBG duzeyleri ile AMH, urokortin 2 ve urokortin 3 duzeyleri arasinda korelasyon gosterilemedi. Sonuc: Bu calismada urokortin 2 ve urokortin 3 ve AMH duzeyleri ile PKOS arasinda iliski saptanamamistir. Bu konuda daha ileri calismalara ihtiyac vardir. Objective: Polycystic ovary syndrome (PCOS) is a frequent endocrine disorder characterized by chronic anovulation and hyperandrogenism, affecting 5 to 10 percent of women in reproductive age. It was aimed in this study to examine serum urocortin 2, urocortin 3 and AMH levels in adolescents with PCOS and to compare the results with those of healthy adolescents. Material and Methods: 37 adolescent girls (16.1±0.98 years) with PCOS diagnosed according to Rotterdam criteria and 39 healthy adolescent girls (16.1±1.08 years) were recruited to the study. All patients’ anthropometric measurements and pubertal development stages were recorded. Hirsutism was scored according to Ferriman-Gallwey scoring system. Insulin resistance was diagnosed when HOMA-IR was >4. Bioelectrical impedance analysis was used to measure body fat percentage and fat free mass. Levels of fasting glucose, insulin, lipids, follicle stimulating hormone, luteinizing hormone, sex hormone binding globulin, free and total testosterone, urocortin 2 and 3, and AMH were measured. Suprapubic pelvic USG was also performed in the PCOS group. Findings: The mean age of the two groups was similar (p>.05). In the PCOS group, body mass index SDS, height SDS and waist circumference SDS was significantly higher than the control group (p .05). There was no significant correlation between hirsutism score and AMH, urocortin 2 and urocortin 3 levels (p>.05). There was a significant positive correlation between AMH, urocortin 2 and urocortin 3, but no correlation was found between LH, FSH, free testosteron, total testosterone, SHBG levels and AMH, urocortin 2 and urocortin 3. Conclusion: This study did not find any relationship between urocortin 2, urocortin 3 and AMH levels and PCOS. Further studies are needed to search about this topic.