Oral antidiabetics and lipids

: Lipid abnormalities are a key factor in the vascular risk of type 2 diabetes. In this review, we briefly consider lipid abnormalities associated with type 2 diabetes. The effects of the main oral antidiabetic agents (sulphonylureas and glinides analogues, metformin, inhibitors of alpha-glucosidase) on lipoproteins are described. Thiazolidinedione (pioglitazone and rosiglitazone) effects on lipid metabolism, as well as their effects on mechanisms involved in the promotion of atherosclerosis are discussed.