Behçet's Disease After H1N1 Vaccination

Background: Behcet’s disease is a chronic, relapsing, multisystemic vasculitis characterized mainly with ulcerations of the oral and genital mucosa, ocular, articular and vascular as well as further organ involvements. The aetiology of Behcet’s disease is unknown. Most widely held hypothesis of the disease pathogenesis is that an altered immune response triggered by an infectious agent or by an auto antigen in a genetically predisposed host. We report a 26-year-old male patient with ulcers of oral and genital mucosa, which had occurred 48 hours after H1N1 vaccination. He was diagnosed as Behcet’s disease with the clinical findings. Since viral and bacterial antigens can precipitate Behcet's disease via triggering immune response, we think that H1N1 vaccination may be precipitant in this case. This is the first case in the literature showing the association of Behcet's disease and H1N1 vaccination.