Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines
1999
Abstract A series of 1-aryl-3-substituted pyrrolo[3,2- c ]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2- c ]quinolines mostly affected the in vitro H + /K + ATPase activity, 1-aryl substituents of pyrrolo[3,2- c ]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.
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