Co(II)-induced giant vibrational CD provides a new design of methods for rapid and sensitive chirality recognition

We designed a stereodynamic system, where the chirality of the analyte serves as a template for the helicity of the first coordination sphere of Co(II). Giant VCD bands induced by Co(II) allow the measurement of a completely significant and conclusive VCD spectrum in only a few seconds and/or on minute quantities of the analyte. This paves the way for the development of similar protocols, overcoming the limitations due to weak VCD signals for the assignment of absolute configurations.