A non-peptide angiotensin II receptor antagonist: 2-butyl-6-methyl-5-(1-oxopyrid-2-yl)-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazo[5,4-b]pyridine methanol solvate

The title compound, C 30 H 28 N 8 O.CH 4 O, is one of a series of imidazo[5,4-b]pyridine-based angiotensin II receptor antagonists showing high antihypertensive activity. The overall conformation of the biphenyl-tetrazole moiety as well as its relative orientation with respect to the central fused ring is significantly different from those of related compounds, indicating that this class of compounds has considerable conformational flexibility.