Synthesis of 3β-Hydroxy-24-norchol-5-en-23-oic Acid

The synthesis of 3β-hydroxy-24-norchol-5-en-23-oic acid, an anti-inflammatory marine natural product, was achieved from commercial available 16-dehydropregnenolone acetate in six steps with a 28.2% overall yield. The key step was palladium catalyzed allylation.