4-o- sulfatase its coding gene and application of endo-chondroitin sulfate / dermatan sulfate

The present invention relates to an endo-chondroitin sulfate / dermatan sulfate sulfatase its coding gene and application of 4-O-. The present invention first discloses the nucleotide sequences and the amino acid sequence of the gene encoding the endo-chondroitin sulfate / dermatan sulfate sulfatase 4-O-. After testing, the enzyme has endo-type high sulfatase activity, and the internal end of sulfate polysaccharides are off action can be effectively applied to the polysaccharide, the internal structure of the polysaccharide is modified adjustment, applied to the preparation brain injury repair, regulation of metabolism and the treatment of inflammation and cancer drugs. CGMCC NO. 8913 20140312