The leftward deletion 4.2 KB alpha-thalassemia in two sickle cell anemia siblings

The presence of –?thal 3.7Kb deletion is associated with better prognosis of Sickle Cell Anemia (SCA) patients, but here are not reports in the literature regarding association of –? thal 4.2Kb and its importance among SCA clinical outcome. In this report, we describe Hemoglobin profile and laboratory findings of two siblings who have SCA and are silent carriers of –? thal 4.2Kb. Both described patients have severe anemia, lower rates of Mean Corpuscular Volume (MCV) and a high leukocytes count. Further studies are required to establish a possible association between –? thal 4.2Kb and SCA severity. Keywords: Alpha thalassemia, sickle cell anemia, hemoglobin.