Disseminated Primary Non-Hodgkin's Lymphoma of Bone: A Case Report

Primary lymphoma of bone is uncommon and disseminated non-Hodgkin’ s lymphoma is extremely rare. The authors report a case of primary non-Hodgkin’ s lymphoma of bone involving the whole skeleton without evidence of invo l vement of lymph nodes or other tissue. Radiographic examination demonstrated moth-eaten or p e r m e a t i ve bone destruction with endosteal scalloping. The MRI revealed hypointense bone marrow to fat on T2 weighted image before treatment. Bone marrow biopsy and subsegment immunohistochemical studies demonstrated the presence of n o n - H o d g k i n’ s lymphoma, T-cell type. The patient underwent standard chemotherapy and showed marked resolution, clinically and radiologically.