The features of N-methyl-D-aspartate receptor in neuron of hip pocampus of mice with vascular dementia by immunohistochemistry

Objective The characteristics of N-methyl-D-aspartate receptor in neuron of hippocampus of mice with vascular dementia (VD ) were observed for the purpose of demonstrating its function in VD pathogenesis .Methods The mice were subjected for ischemia-reperfusion repe atedly in bilateral common carotid arteries by knotting to establish the VD mode ls.The behavior abnormalities were investigated by step-down test and water m aze test,and the N-methyl-D-aspartate receptor was observed by immunohistoch emistry technique.Results The grades of learning and memory in VD mice were worse than those in sham-operation group(P0.01),and the exp ression of N-methyl-D-aspartate receptor in VD mice was also lower than that of sham-operation group(P0.01).Conclusion The poor grade s of learning and memory in VD mice are related to the decrease of N-methyl-D -aspartate receptor in neuron of hippocampus.