Alteration of VEGF and Angiopoietins Expressions in Diabetic Glomeruli Implicated in the Development of Diabetic Nephropathy

Etiologies of diabetic nephropathy are largely unknown. Recent investigations have shed light on the potent roles of growth factors in the development of diabetic nephropathy. We investigated the glomerular expression of vascular endothelial growth factor-A (VEGF-A), Angiopoiein-1(Ang-1) and Angiopoietin-2 (Ang-2) in diabetic condition and the effects of those factors on the glomerular endothelial gene