Synthesis of novel 1,4-disubstituted 1,2,3-triazoles bearing organosilicon-sulfur groups via the click reaction sonocatalyzed by LaCuxMn1-xO3 nanoparticles

ABSTRACTA highly efficient and environmentally friendly one-pot procedure for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of benzyl halides, terminal alkynes, and sodium azide over LaCuxMn1-xO3 perovskite oxides was developed. LaCu0.7Mn0.3O3 was found to be active with low catalyst loading under ultrasonic irradiation in aqueous media. The reaction was performed efficiently in the presence of the nanocatalyst in the absence of any additive or base with a noticeable reduction in the reaction time. The catalyst could be recycled and reused at least five times without any significant effect on the results of the reaction. Moreover, a series of novel organosilicon-sulfur substituted 1,2,3-triazole derivatives was synthesized using carbon disulfide and tris(trimethylsilyl)methylithium.