Nonalcoholic Fatty Liver Disease and Cardiac Remodeling Risk: Pathophysiological Mechanisms and Clinical Implications.

With dramatic increases in obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver diseases, affecting approximately one-quarter of adults worldwide. It is noteworthy that patients with NAFLD die from cardiovascular diseases (CVDs) more frequently than from the liver disease itself. Pathophysiological cardiac remodeling, categorized into cardiac electrical remodeling and structural remodeling, is one of the most common causes of heart failure and mortality. Therefore, mechanistic links and clinical relevance between NAFLD and cardiac remodeling worth to be highly recognized. In this review, we highlight the potential mechanisms linked NAFLD to the development of cardiac remodeling and summarize the clinical evidence demonstrating the tight connections between these two entities.